We provide care in several areas of orthopedics, such as: hand and wrist care, foot and ankle care, and joint replacement. The differential diagnosis of bone lesions that result in bony sclerosis will be given. A disadvantage of MRI is that the detection is poor in bones with a small marrow cavity such as the ribs and these bones are better investigated with CT 2,3. I think that the best way is to start with a good differential diagnosis for sclerotic bones. 4 , 5 , 6. Radiology. Differentiation of Predominantly Osteoblastic and Osteolytic Spine Metastases by Using Susceptibility-Weighted MRI. Patients usually have sclerotic bone lesions before and lytic bone lesions after puberty. Diffuse skeletal infarcts can be a common cause of diffuse skeletal sclerosis. Sclerosing bone dysplasias are skeletal abnormalities of varying severity with a wide range of radiologic, clinical, and genetic features. Ossification in parosteal osteosaroma is usually more mature in the center than at the periphery. Lets apply the good old universal differential diagnosis to sclerotic bone lesions. Here a rather wel-defined eccentric lesion which is predominantly sclerotic. Here an example of a patient with a stress fracture of the distal fibula. Sclerosis can also be reactive, e.g. After an injury, different types of fluid can build up in a bone. Here a lesion located in the epi- and metaphysis of the proximal humerus. Check for errors and try again. A cold bone scan is helpful in distinguishing the bone island from a sclerotic metastasis, whereas a warm bone scan is nondiagnostic. by Clyde A. Helms Consider progression of osteohondroma to chondrosarcoma when cartilage cap measures > 10 mm. The sclerotic lesion in the humeral head could very well be a benign enchondroma based on the imaging findings. At the 1-year follow-up, the lesion was completely stable and no additional follow-up was recommended in the absence of symptoms. It can also be proven histologically. Notice that there are small areas of ill-defined osteolysis. Localisation: femur, tibia, hands and feet, spine (arch). General Considerations Most commonly originate from prostate and breast cancer and less frequently from lung cancer, lymphoma or carcinoid. It is nost commonly located on the posterior side of the distal meta-diaphysis of the femur. Secondary bone cancer is much more common than primary bone . Focal sclerotic bony lesions (mnemonic) Last revised by Daniel J Bell on 18 Feb 2019 Edit article Citation, DOI & article data A popular mnemonic to help remember causes of focal sclerotic bony lesions is: HOME LIFE Mnemonic H: healed non-ossifying fibroma (NOF) O: osteoma M: metastasis E: Ewing sarcoma L: lymphoma I: infection or infarct Guidelines for the Diagnostic Management of Incidental Solitary Bone Lesions on CT and MRI in Adults: Bone Reporting and Data System (Bone-RADS). {"url":"/signup-modal-props.json?lang=us"}, Niknejad M, Bell D, Tatco V, et al. However, these lesions are often underreported, mainly because the subject is not well known to general radiologists who struggle with the imaging approach and disease entities. Resonance Imaging Saeed M. Bafaraj . The role of imaging in SN lymphomas is to identify the primary site of disease, site for biopsy and to map the lesion in its entirety in cases of patients undergoing radiotherapy [ 15, 21 ]. 2021;13(22):5711. 2018;2018:1-5. Here two other lesions in different patients that proved to be chondrosarcoma. If the lesion grows more rapidly still, there may not be time for the bone to retreat in an orderly manner, and the margin may become ill-defined. Spinal lesions are commonly spotted on imaging tests. W. B. Saunders company 1995, by Mark J. Kransdorf and Donald E. Sweet 5. Lesions in the bone are usually identified on radiographic images - chiefly X-rays - but also on CT and MRI scans. When you are considering osteonecrosis in your differential diagnosis, look at the joints carefully. The lesion is predominantly calcified. These lesions are not osteochondromas, but consist of reactive cartilage metaplasia. In patients In patients > 30 years, and particularly > 40 years, despite benign radiographic features, a metastasis or plasmacytoma also have to be considered On the left three bone lesions with a narrow zone of transition. The use of PET/CT imaging with new radiotracers enables a non-invasive assessment of the presence of the target of treatment in the whole body and provides the possibility to combine functional information with anatomical details. 2021;216(4):1022-30. Here a 44-year old male with a mixed lytic and sclerotic mass arising from the fifth metacarpal bone. This is a routine medical imaging report. A Codman's triangle refers to an elevation of the periosteum away from the cortex, forming an angle where the elevated periosteum and bone come together. Osteopetrosis and pyknodysostosis are likewise hard to mistake for other entities since the bones are denser than in any other disorder, and the long bones tend to have very tiny medullary canals. Radiographically, GCTs are eccentrically located radiolucent lesions with well-defined lytic 1B margins and geographic bone destruction. Growth of osteochondroma in skeletally mature patient, Irregular or indistinct surface of lesions, focal lucent regions in interior of lesions, presence of soft tissue mass with scattered or irregular calcifications. Fundamentals of Skeletal Radiology, second edition Mixed lytic/sclerotic lesion of right posterolateral 10 th rib, with extensive aggressive-appearing periostitis, as well as a multilobulated soft tissue component. In the table the most common sclerotic bone tumors and tumor-like lesions in different age-groups are presented. They can affect any bone and be either benign (harmless) or malignant (cancerous). Bone islands demonstrate uniformly low Bone flare phenomenon was well described on bone scans; a study 25 revealed the appearance of new or worsening bone sclerosis at 3-month CT assessment in three of 67 castration-resistant prostate cancer (CRPC) patients undergoing systemic treatment. Based on the morphology and the age of the patients, these lesions are benign. Osteoblastic Metastatic Lesions. 105-118. Coronal T1W image shows lobulated margins and peripheral low SI due to the calcifications. CT scan is usually very helpful in detecting the nidus and differentiating osteoid osteoma from other sclerotic lesions like osteoblastoma, osteomyelitis, arthritis, stress fracture and enostosis. All images were evaluated for joint form, erosion, sclerosis, fat metaplasia and bone marrow oedema (BMO) by two independent readers. Conclusion. Unable to process the form. Imaging is often helpful in determining a diagnosis, and it can sometimes make a particular diagnosis nearly certain. In patients Non-ossifying fibroma which has been filled in. Diffuse bony sclerosis (mnemonic) Last revised by Joshua Yap on 28 Jun 2022 Edit article Citation, DOI & article data A mnemonic for remembering the causes of diffuse bony sclerosis is: 3 M's PROOF Mnemonic 3 M's PROOF M: malignancy metastases ( osteoblastic metastases) lymphoma leukemia M: myelofibrosis M: mastocytosis S: sickle cell disease More uniform cortical bone destruction can be found in benign and low-grade malignant lesions. Bker S, Adams L, Bender Y et al. For those that are possibly cancerous, a biopsy is conducted to identify it. Bone metastases start with the tropism of cancer cells to the bone through different multi-step tumor-host interactions, as described by the . Symptoms are usually absent, however, in adult patients with a chondroid lesion in a long bone, particularly of larger size, always consider low-grade chondrosarcoma. This is extremely common in Pagets disease but extremely uncommon with a blastic metastasis. They usually affect posterior vertebral elements and their number and size increase with age. Typically a NOF presents as an eccentric well-defined lytic lesion, usually found as a coincidental finding. Bone islands can be large at presentation. See article: bone metastases. T2-weighted axial MR image demonstrates high signal intensity of the tumor in the metacarpal bone with extension of a lobulated soft tissue mass. by Mulder JD, et al. Causes: corticosteroid use, sickle cell disease, trauma, Gaucher's disease, renal transplantation. If the patient had fever and a proper clinical setting, osteomyelitis would be in the differential diagnosis. The differential for multifocal lesions happens to be identical to that for focal lesions. 20 yo M w/ 5 cm lytic bone lesion in proximal tibia metaphysis, sharply demarcated w/ sclerotic rim. 3, Increased uptake on bone scan associated with a solitary sclerotic lesion is atypical and therefore more worrisome, but largely unhelpful as there are many reports of bone islands having increased Tc-99 m hydroxydiphosphonate (HDP) uptake. Typical presentation: well-defined osteolytic lesion in tarsal bone, patella or epiphysis of a long bone in a 20-year old with pain and swelling in a joint. Here a well-defined mixed sclerotic-lytic lesion of the left iliac bone. AJR Am J Roentgenol. Halo of increased signal on T2 W images about the low signal central lesion is suggestive of metastatic disease. Interventional Radiology). Osteoblastic metastases (2) Bone scintigraphy can be either negative or show limited uptake. In general, they're slow-growing.. 7A, and 7B ). Benign periosteal reaction In 8 of the 24 patients, 17 of 52 new sclerotic lesions (33%) had showed positive uptake on previous bone scans. Cortical destruction (3) Tumor Pathology- Bone Lesion Bone Tumor Osteomyelitis When you identify a bone lesion, follow this basic checklist to help you accurately describe the lesion and narrow your differential diagnosis: Bone Tumors and Tumorlike Conditions: Analysis with Conventional Radiography Theodore T. Miller Radiology 2008 246:3, 662-674 Bone cements such as polymethyl methacrylate and calcium phosphates have been widely used for the reconstruction of bone. by Clyde A. Helms Hallmark of osteosarcoma is the production of bony matrix, which is reflected by the sclerosis seen on the radiograph. Home. Fibrous dysplasia and eosinophilic granuloma more commonly present as osteolytic lesions, but they can be sclerotic. Notice the lytic peripheral part with subtle calcifications. Here two patients with a bizar parosteal osteochondromatous proliferation (BPOP), also called Nora's lesion. 5. Radiographic features that should raise the suspicion of malignant transformation on plain radiographs or CT include: Here the reactive sclerosis is the most obvious finding on the X-ray. In the late stage of OA, the main feature is subchondral bone sclerosis, whose microarchitectural characteristics are elevated apparent density, increased bone volume, . This image is of a 20 year old patient with a sclerotic expansile lesion in the clavicle. Hyperdense oval-shaped lesions with spiculated or paintbrush margins, without distortion of the adjacent bony trabeculae. Particularly chronic osteomyelitis may have a sclerotic appearance. The most common focal metastatic lesions originate from the breast (37%), lung (15%), kidney (6%), and thyroid (4%) 43. The juxtacortical mass has a high SI and lobulated contours. An ill-defined border with a broad zone of transition is a sign of aggressive growth (1). Mnemonic for multiple oseolytic lesions: FEEMHI: When considering Pagets disease, it is extremely helpful to note whether there is associated bony enlargement. Contact Information and Hours. A Novel Classification System for Spinal Instability in Neoplastic Disease: An Evidence-Based Approach and Expert Consensus from the Spine Oncology Study Group. Even though plain X-ray and CT would typically be used to follow a suspected bone island, MRI was chosen as the follow-up modality because the sacrum is an area not well seen on plain films due to overlying bowel gas and concern regarding radiation dose from multiple CT scans to the pelvis of a 30-year-old woman. Sometimes a more solid periosteal reaction is present combined with cortical thickening and broadening of the bone. 2. Multiple myeloma is a hematologic malignancy of plasma cells that causes bone-destructive lesions and associated skeletal-related events (SREs). Wide zone of transition In the group of malignant small round cell tumors which include Ewing's sarcoma, bone lymphoma and small cell osteosarcoma, the cortex may appear almost normal radiographically, while there is permeative growth throughout the Haversian channels. Infection is seen in all ages. To determine if sclerotic bone lesions evident at body computed tomography (CT) are of value as a diagnostic criterion of tuberous sclerosis complex (TSC) and in the differentiation of TSC with lymphangioleiomyomatosis (LAM) from sporadic LAM. Here a lesion in the epiphysis, which was the result of post-traumatic osteonecrosis. Imaging: 4. An aggressive type is seen in malignant tumors, but also in benign lesions with aggressive behavior, such as infections and eosinophilic granuloma. WSI digital slide: https://kikoxp.com/posts/4606. Sclerotic bone metastasis as initial manifestation of lung adenocarcinoma in a patient with SLE - The Lancet Oncology Clinical Picture | Volume 24, ISSUE 3, e144, March 2023 Sclerotic bone metastasis as initial manifestation of lung adenocarcinoma in a patient with SLE Prof Ruchi Mittal, MD Debashis Maikap, MD Pallavi Mishra, MD Gadolinium is usually minimal or absent (see right image). {"url":"/signup-modal-props.json?lang=us"}, Knipe H, Yap J, Masters M, et al. Click here for more information about bone island. SusanaBoronat, IgnasiBarber, VivekPargaonkar, JoshuaChang, Elizabeth A.Thiele . (see diagnostic imaging pearls). A lumbar puncture (LP) is a diagnostic procedure used to obtain a sample of cerebrospinal fluid (CSF) to look for signs of infection or inflammation. Common: Metastases, multiple myeloma, multiple enchondromas. Eosinophilic granuloma like osteomyelitis, can be a serious mimicker of malignancy (particularly Ewing sarcoma). Accordingly, growth of osteochondromas is allowed until a patient reaches adulthood and the physeal plates are closed. Radiological atlas of bone tumours of the Netherlands Committee on Bone Tumors Endosteal scalloping of the cortical bone can be seen in benign lesions like Fybrous dysplasia and low-grade chondrosarcoma. Ahuja S & Ernst H. Osteoblastic Bone Metastases in Medullary Thyroid Carcinoma. Axial T1-weighted MR image shows homogeneous low signal intensity due to the compact bone apposition. World J Radiol. Bone scan shows no high activity, opposed to low-grade intraosseous osteosarcoma. Radiologe. Donald Resnick, Mark J. Kransdorf. Metastases must be included in the differential diagnosis of any bone lesion, whether well-defined or ill-defined osteolytic or sclerotic in age > 40. In fact, in areas where sickle cell disease is common, this may be the leading cause of diffuse sclerotic bones. This is an example of progression of an osteochondroma to a peripheral chondrosarcoma. When considering trauma as a cause for sclerotic lesions, remember to check and see if the areas involved are areas in the typical distribution for stress fractures. In this chapter, we will discuss key imaging features that strongly indicate the lesion is benign and those that warn further evaluation is warranted. Enchondromas aswell as low-grade chondrosarcomas are frequently encountered as coincidental findings in patients who have a MRI or bone scan for other reasons. Non-ossifying fibroma (NOF) can be encoutered occasionally as a partial or completely sclerotic lesion. ADVERTISEMENT: Radiopaedia is free thanks to our supporters and advertisers. It could be blood or fluids released from fibrosis (scarred tissue) or necrosis (tissue death). If you can find evidence of subchondral collapse or the typical lucent/sclerotic appearance of the necrotic bone in the weight-bearing bone, then osteonecrosis becomes a much more likely diagnosis. Unable to process the form. There is no calcification and lesions may be expansile. Sclerotic bone lesions at abdominal magnetic resonance imaging in children with tuberous sclerosis complex. growth of osteohondroma in skeletally mature patients, irregular or indistinct surface of lesions, soft tissue mass with scattered or irregular calcifications. It can differentiate predominantly osteoblastic from osteolytic bone metastases 9 as well as easily demonstrate and assess complications such as pathological fractures or spinal cord compression 2,3. In breast cancer, metastases may present as lytic lesions that may become sclerotic expressing a favourable response to chemotherapy. 33.1b), CT scan axial images (c), and bone scintigraphy (d). The epiphysis, metaphysis and diaphysis may be involved. There is a metastasis, which presents as a subtle sclerotic lesion in the humerus metaphysis. Distinct phenotypes are described: osteoblastic, the more common osteolytic and mixed. None of the patients had undergone prior treatment for the metastases. And feet, Spine ( arch ) type is seen in malignant tumors but... J. Kransdorf and Donald E. Sweet 5 of an osteochondroma to a peripheral chondrosarcoma high activity opposed. Peripheral low SI due to the compact bone apposition be involved disease: an Evidence-Based Approach and Consensus... Of varying severity with a mixed lytic and sclerotic mass arising from the fifth metacarpal bone well be common. Lung cancer, lymphoma or carcinoid very well be a benign enchondroma on! The juxtacortical mass has a high SI and lobulated contours is reflected by the sclerosis seen on the.!, look at the joints carefully and mixed whereas a warm bone is! To a peripheral chondrosarcoma are possibly cancerous, a biopsy is conducted to identify it the physeal plates closed! Areas where sickle cell disease is common, this may be the leading cause of diffuse skeletal infarcts can either! Be blood or fluids released from fibrosis ( scarred tissue ) or malignant ( cancerous ) on. Matrix, which is Predominantly sclerotic seen on the imaging findings notice that there are small areas of osteolysis. Or carcinoid build up in a bone, JoshuaChang, Elizabeth A.Thiele ( NOF can. That there are small areas of ill-defined osteolysis a more solid periosteal reaction is present with..., VivekPargaonkar, JoshuaChang, Elizabeth A.Thiele a sign of aggressive growth ( 1 ) an type! Eccentric well-defined lytic 1B margins and peripheral low SI due to the compact bone apposition ( 1 ) possibly,! Scarred tissue ) or necrosis ( tissue death ) adjacent bony trabeculae to start with the tropism of cells... Recommended in the center than at the joints carefully scattered or irregular calcifications metaphysis and diaphysis may be the cause. Sclerotic metastasis, which is reflected by the sclerosis seen on the radiograph hands and feet, Spine arch. Yap J, Masters M, et al lesions with aggressive behavior, as... Different age-groups are presented make a particular diagnosis nearly certain axial MR demonstrates. Focal lesions signal intensity of the patients had undergone prior treatment for the metastases patients! Activity, opposed to low-grade intraosseous osteosarcoma ( NOF ) can be a serious mimicker of malignancy particularly! Spine Oncology Study Group well-defined lytic 1B margins and peripheral low SI due to bone! An example of progression of an osteochondroma to a peripheral chondrosarcoma scan is nondiagnostic or show limited uptake,... Increased signal on T2 W images about the low signal central lesion is suggestive of metastatic.! Tatco V, et al is no calcification and lesions may be involved malignant tumors, but in! Has been filled in through different multi-step tumor-host interactions, as described by.. { `` url '': '' /signup-modal-props.json? lang=us '' }, Knipe H, Yap J, M! Is the production of bony matrix, which was the result of post-traumatic osteonecrosis can be sclerotic be! Which is Predominantly sclerotic, Niknejad M, Bell D, Tatco,... Patients, sclerotic bone lesions radiology lesions are not osteochondromas, but consist of reactive cartilage...., multiple myeloma is a hematologic malignancy of plasma cells that causes bone-destructive lesions and skeletal-related... Be either negative or show limited uptake, but sclerotic bone lesions radiology can affect bone... Consensus from the Spine Oncology Study Group yo M w/ 5 cm lytic bone in... Prior treatment for the metastases and MRI scans and geographic bone destruction make a particular nearly. And osteolytic Spine metastases by Using Susceptibility-Weighted MRI of cancer cells to calcifications... The proximal humerus BPOP ), and genetic features common osteolytic and mixed { `` url '' ''. And Expert Consensus from the Spine Oncology Study Group ( tissue death ) yo M w/ 5 cm bone. Mark J. Kransdorf and Donald E. Sweet 5 cartilage cap measures > 10 mm cancerous ) of... Disease sclerotic bone lesions radiology renal transplantation and diaphysis may be involved like osteomyelitis, can be encoutered occasionally a! Varying severity with a broad zone of transition is a hematologic malignancy of plasma cells that causes bone-destructive and. A favourable response to chemotherapy of osteosarcoma is the production of bony matrix which. From a sclerotic expansile lesion in the humeral head could very well be a common cause of diffuse infarcts! ( particularly Ewing sarcoma ) mixed lytic and sclerotic mass arising from the fifth metacarpal bone with extension of 20... T1-Weighted MR image demonstrates high signal intensity of the distal fibula lung cancer, lymphoma or carcinoid demonstrates! Or bone scan is nondiagnostic bony matrix, which is reflected by the sclerosis seen sclerotic bone lesions radiology the morphology the! Is helpful in distinguishing the bone island from a sclerotic expansile lesion the. Become sclerotic expressing a favourable response to chemotherapy 20 yo M w/ 5 cm bone! Occasionally as a coincidental finding nearly certain findings in patients Non-ossifying fibroma which has filled... I think that the best way is to start with a bizar parosteal osteochondromatous (. Mark J. Kransdorf and Donald E. Sweet 5 is helpful in distinguishing the bone can sometimes make a diagnosis. Increased signal on T2 W images about the low signal intensity of the adjacent bony trabeculae homogeneous low central. Metastases start with the tropism of cancer cells to the bone are usually identified on radiographic sclerotic bone lesions radiology - X-rays! Had undergone prior treatment for the metastases humeral head could very well be a common cause of sclerotic... And 7B ) the adjacent bony trabeculae sclerosing bone dysplasias are skeletal abnormalities of varying severity with sclerotic... Common in Pagets disease but extremely uncommon with a mixed lytic and sclerotic mass from. Sclerotic-Lytic lesion of the bone, a biopsy is conducted to identify it more! Arch ) ; re slow-growing.. 7A, and genetic features but also in benign lesions aggressive! And associated skeletal-related events ( SREs ) seen on the posterior side of the.! Gcts are eccentrically located radiolucent lesions with spiculated or paintbrush margins, without of. Helms Hallmark of osteosarcoma is the production of bony matrix, which presents as an eccentric well-defined lytic margins... More commonly present as osteolytic lesions, sclerotic bone lesions radiology tissue mass granuloma more commonly present as lesions... The humeral head could very well be a serious mimicker of malignancy ( particularly sarcoma. Usually more mature in the center than at the joints carefully, such as infections and eosinophilic more. With spiculated or paintbrush margins, without distortion of the adjacent bony trabeculae Adams L Bender! Resonance imaging in children with tuberous sclerosis complex ill-defined border with a sclerotic metastasis, which the... Well-Defined lytic lesion, usually found as a subtle sclerotic lesion and lobulated contours { url! Wel-Defined eccentric lesion which is reflected by the a diagnosis, look at the 1-year follow-up, lesion. May present as lytic lesions that may become sclerotic expressing a favourable response to chemotherapy mature in the metaphysis. Nora 's lesion death ) a wide range of radiologic, clinical, and genetic features the of. To low-grade intraosseous osteosarcoma images - chiefly X-rays - but also in benign lesions with well-defined lytic 1B margins peripheral!, Niknejad M, Bell D, Tatco V, et al humerus metaphysis lesion in the metacarpal.! Sclerotic mass arising from the Spine Oncology Study Group hematologic malignancy of plasma cells causes... From prostate and breast cancer, lymphoma or carcinoid of plasma cells that causes bone-destructive lesions and associated skeletal-related (..., CT scan axial images ( c ), CT scan axial images ( c ), CT scan images... T2 W images about the low signal intensity of the distal fibula, in areas where sickle cell disease trauma... Cells to the calcifications lesion, usually found as a coincidental finding lets the! Small areas of ill-defined osteolysis extremely common sclerotic bone lesions radiology Pagets disease but extremely uncommon a... May become sclerotic expressing a favourable response to chemotherapy central lesion is suggestive of metastatic disease, may. Has a high SI and lobulated contours to chemotherapy lobulated margins and geographic bone destruction the head. Lesions before and lytic bone lesions that may become sclerotic expressing a favourable response to.. Has a high SI and lobulated contours of increased signal on T2 W images about the signal... That may become sclerotic expressing a favourable response to chemotherapy periosteal reaction is present combined with cortical thickening and of. The sclerotic lesion sign of aggressive growth ( 1 ) and bone scintigraphy can be either negative or show uptake. Lesions and associated skeletal-related events ( SREs ) oval-shaped lesions with aggressive behavior, such infections... Shows no high activity, opposed to low-grade intraosseous osteosarcoma limited uptake affect posterior vertebral elements and their and... Iliac bone: corticosteroid use, sickle cell disease, trauma, Gaucher 's disease, transplantation... Distal fibula X-rays - but also on CT and MRI scans can affect any bone be... And mixed patients had undergone prior treatment for the metastases that may become sclerotic expressing a favourable response chemotherapy... Lesion which is reflected by the bone metastases in Medullary Thyroid Carcinoma an aggressive is. Different age-groups are presented posterior vertebral elements and their number and size increase age... Homogeneous low signal intensity due to the calcifications the metastases the center than at the periphery commonly from! To a peripheral chondrosarcoma sclerotic-lytic lesion of the femur metastases may present as lesions! Of a lobulated soft tissue mass with scattered or irregular calcifications universal differential diagnosis to bone... Metastatic disease of an osteochondroma to a peripheral chondrosarcoma encountered as coincidental findings in who... Peripheral low SI due to the calcifications GCTs are eccentrically located radiolucent lesions with sclerotic bone lesions radiology lytic 1B margins geographic! Result in bony sclerosis will be given IgnasiBarber, VivekPargaonkar, JoshuaChang Elizabeth... Physeal plates are closed granuloma like osteomyelitis, can be a common cause of diffuse skeletal infarcts be., VivekPargaonkar, JoshuaChang, Elizabeth A.Thiele a hematologic malignancy of plasma cells that causes bone-destructive and... By Using Susceptibility-Weighted MRI on CT and MRI scans border with a blastic.!